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Cognitive function in schizophrenic patients.
- Source :
-
The Journal of clinical psychiatry [J Clin Psychiatry] 1996; Vol. 57 Suppl 11, pp. 31-9. - Publication Year :
- 1996
-
Abstract
- Cognitive impairment is a relatively frequent aspect of schizophrenia. Deficits are most prominent in tasks involving attention, memory, and executive function. Although some research suggests that deterioration is progressive, these deficits appear to be relatively stable over time. Imaging and biochemical studies show that schizophrenia is characterized by a number of morphological, hemodynamic, and neurochemical abnormalities within systems integrating the cortex, temporal lobes, and various limbic structures. Neurochemical assays suggest that the neurotransmitters serotonin, dopamine, and glutamate play a significant role in the disease-associated decrement. Cognitive impairment in schizophrenia impedes psychosocial performance and eventual reintegration into society and is therefore an especially relevant target in the development of new therapeutic modalities. Atypical agents, such as clozapine and olanzapine, hold special promise in this area.
- Subjects :
- Antipsychotic Agents therapeutic use
Benzodiazepines
Cerebral Cortex physiopathology
Clozapine therapeutic use
Cognition Disorders physiopathology
Cognition Disorders psychology
Dopamine physiology
Glutamic Acid physiology
Humans
Limbic System physiopathology
Olanzapine
Pirenzepine analogs & derivatives
Pirenzepine therapeutic use
Schizophrenia drug therapy
Schizophrenia physiopathology
Serotonin physiology
Cognition Disorders diagnosis
Schizophrenia diagnosis
Schizophrenic Psychology
Subjects
Details
- Language :
- English
- ISSN :
- 0160-6689
- Volume :
- 57 Suppl 11
- Database :
- MEDLINE
- Journal :
- The Journal of clinical psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 8941169