Back to Search
Start Over
Increased plasma human immunodeficiency virus type 1 burden following antigenic challenge with pneumococcal vaccine.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1996 Dec; Vol. 174 (6), pp. 1191-9. - Publication Year :
- 1996
-
Abstract
- Primary factors that influence virus burden during human immunodeficiency virus type 1 (HIV-1) disease progression remain a fundamental issue in pathogenesis. Because pneumococcal vaccine is routinely given to HIV-1-infected patients and replication of HIV-1 within CD4 T cells is dependent on the activation state of the cell, it was investigated whether the T cell activation that enhances the immune response to vaccines may also enhance HIV-1 replication. Vaccination of asymptomatic HIV-1-infected patients led to rapid and significant increases in virus burden in some patients. The magnitude of these increases correlated significantly with the extent of the antibody response to the vaccination. Thus, antigenic stimulation by vaccines designed to prevent secondary infections may promote HIV-1 replication in certain patients. These findings provide a window for examining HIV-1 pathogenesis and for determining the appropriate preventive measures against other diseases in HIV-1-infected persons.
- Subjects :
- Adult
Anti-HIV Agents therapeutic use
Antibodies, Bacterial analysis
CD4 Lymphocyte Count
CD8-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes virology
DNA, Viral analysis
Didanosine therapeutic use
Disease Progression
HIV Infections drug therapy
HIV-1 pathogenicity
Humans
Immunoglobulin G analysis
Influenza Vaccines immunology
Lymphocyte Activation
Middle Aged
Polysaccharides, Bacterial immunology
Proviruses genetics
RNA, Viral analysis
Receptors, Interleukin-2 immunology
Time Factors
Vaccination adverse effects
Zidovudine therapeutic use
CD4-Positive T-Lymphocytes immunology
CD4-Positive T-Lymphocytes virology
HIV Infections immunology
HIV Infections virology
HIV-1 growth & development
Pneumococcal Infections immunology
Pneumococcal Infections prevention & control
Vaccines adverse effects
Vaccines immunology
Viral Load
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 174
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 8940208
- Full Text :
- https://doi.org/10.1093/infdis/174.6.1191