Clinical positron emission tomography for brain tumors: comparison of fludeoxyglucose F 18 and L-methyl-11C-methionine.

Authors :: Ogawa T
Inugami A
Hatazawa J
Kanno I
Murakami M
Yasui N
Mineura K
Uemura K
Source :: AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 1996 Feb; Vol. 17 (2), pp. 345-53.
Publication Year :: 1996
Abstract: Purpose: To evaluate the differences between fludeoxyglucose F 18 (FDG) and L-methyl-11C-methionine (11C-methionine) as tracers for positron emission tomography (PET) in the evaluation of brain tumors.<br />Methods: We analyzed 10 patients with histologically verified cerebral glioma or meningioma and 1 patient with a neuroradiologic diagnosis of low-grade glioma by using FDG, 11C-methionine, and PET. We qualitatively and quantitatively evaluated the extent and degree of accumulation of FDG and 11C-methionine in the tumor tissue.<br />Results: Although PET with FDG depicted malignant tumors as a hot spot in all cases, it was not able to delineate the extent of the tumor. Conversely, PET with 11C-methionine outlined the tumors as areas of increased accumulation of 11C-methionine, regardless of the degree of malignancy.<br />Conclusion: PET with FDG and with 11C-methionine can play complementary roles in the evaluation of brain tumors.

Subjects :: Fluorodeoxyglucose F18
Glioma diagnostic imaging
Image Processing, Computer-Assisted
Meningeal Neoplasms diagnostic imaging
Meningioma diagnostic imaging
Blood Glucose metabolism
Brain Neoplasms diagnostic imaging
Carbon Radioisotopes
Deoxyglucose analogs & derivatives
Fluorine Radioisotopes
Methionine analogs & derivatives
Tomography, Emission-Computed

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