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A nonsense mutation (Arg-196-Term) in exon 6 of the human TP53 gene identified in small cell lung carcinoma.
- Source :
-
Molecular and cellular probes [Mol Cell Probes] 1996 Oct; Vol. 10 (5), pp. 393-5. - Publication Year :
- 1996
-
Abstract
- In a search for mutations of the TP53 tumour suppressor gene in lung cancer samples from gold miners in the Witwatersrand, South Africa, using heteroduplex and single strand conformation polymorphism (SSCP) analysis, a nonsense mutation was found in exon 6, consisting of a C to T transition and resulting in chain termination of the TP53 gene. The mutation occurred in a small cell lung cancer sample and is the first reported codon 196 TP53 mutation in both radon-associated and small cell lung cancer (SCLC) material.
Details
- Language :
- English
- ISSN :
- 0890-8508
- Volume :
- 10
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Molecular and cellular probes
- Publication Type :
- Academic Journal
- Accession number :
- 8910896
- Full Text :
- https://doi.org/10.1006/mcpr.1996.0054