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Syntheses of (14 beta,15 beta,16 beta,17 alpha)- and (14 beta,15 alpha,16 alpha,17 alpha)-1,3,5(10)-estratriene-2,3,14,15,16,17- hexaols, possible candidates for the Inagami--Tamura endogenous digitalis-like factor, and their activity.
- Source :
-
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 1996 Mar; Vol. 60 (3), pp. 405-10. - Publication Year :
- 1996
-
Abstract
- Structures are proposed for the Inagami-Tamura endogenous digitalis-like factor (EDLF), and two possible candidates, (14 beta,15 beta,16 beta,17 alpha)- and (14 beta,15 alpha,16 alpha,17 alpha)-2,3,14,15,16,17-hexahydroxy-1,3,5(10)-estratrienes, were synthesized. Both compounds were potent in inducing a contractile response in isolated rat aorta and guinea pig left atrium.
- Subjects :
- Animals
Aorta drug effects
Cardenolides
Estriol chemical synthesis
Estriol pharmacology
Guinea Pigs
Heart Atria drug effects
In Vitro Techniques
Myocardial Contraction drug effects
Rats
Sodium-Potassium-Exchanging ATPase antagonists & inhibitors
Cardiotonic Agents chemical synthesis
Cardiotonic Agents pharmacology
Digoxin
Estriol analogs & derivatives
Saponins chemical synthesis
Saponins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0916-8451
- Volume :
- 60
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 8901096
- Full Text :
- https://doi.org/10.1271/bbb.60.405