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Different distribution of dihydrolipoamide succinyltransferase, dihydrolipoamide acetyltransferase and ATP synthase beta-subunit in monkey brain.
- Source :
-
In vivo (Athens, Greece) [In Vivo] 1996 Sep-Oct; Vol. 10 (5), pp. 495-501. - Publication Year :
- 1996
-
Abstract
- The distribution of three mitochondrial enzymes: dihydrolipoamide succinyltransferase, dihydrolipoamide acetyltransferase, and beta-subunit of ATP synthase, were examined in the nucleus basalis of Meynert, substantia nigra, locus coeruleus, hippocampus, and cerebral cortex of monkey brain by immunocytochemical staining. Dihydrolipoamide succinyltransferase and dihydrolipoamide acetyltransferase had parallel distribution in the substantia nigra, but dihydrolipoamide acetyltransferase was rich in the locus coeruleus, nucleus basalis of Meynert, and especially in the hippocampus in comparison with dihydrolipoamide succinyltransferase. The ATP synthase beta-subunit was strikingly rich in many neurons of the locus coeruleus and cerebral cortex in comparison with dihydrolipoamide acetyltransferase and dihydrolipoamide succinyltransferase. These results show that these mitochondrial enzymes are not expressed synchronously in the neurons of brain, suggesting the differential regulation of mitochondrial enzymes and the heterogeneity of mitochondria.
- Subjects :
- Acetyltransferases genetics
Acetyltransferases immunology
Acyltransferases genetics
Acyltransferases immunology
Animals
Antibody Specificity
Blotting, Northern
Blotting, Western
Dihydrolipoyllysine-Residue Acetyltransferase
Hippocampus enzymology
Ketoglutarate Dehydrogenase Complex metabolism
Kidney enzymology
Locus Coeruleus enzymology
Macaca
Microscopy, Fluorescence
Myocardium enzymology
Proton-Translocating ATPases genetics
Proton-Translocating ATPases immunology
Pyruvate Dehydrogenase Complex analysis
Pyruvate Dehydrogenase Complex genetics
Pyruvate Dehydrogenase Complex immunology
RNA, Messenger analysis
Rabbits
Substantia Innominata enzymology
Acetyltransferases analysis
Acyltransferases analysis
Brain enzymology
Proton-Translocating ATPases analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0258-851X
- Volume :
- 10
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- In vivo (Athens, Greece)
- Publication Type :
- Academic Journal
- Accession number :
- 8899428