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Role of atheroma liposomes and malondialdehyde-modified low-density lipoproteins in complement activation.
- Source :
-
Pathobiology : journal of immunopathology, molecular and cellular biology [Pathobiology] 1996; Vol. 64 (2), pp. 73-8. - Publication Year :
- 1996
-
Abstract
- We investigated the ability of atheroma-associated liposomes and malondialdehyde (MDA)-modified low-density lipoproteins (MDA-LDL) to activate complement. Complement activation markers C3a, Bb, C4d and SC5b-9 were measured in both normal and complement-deficient sera. We found that MDA-LDL was able to generate C3a and SC5b-9, predominantly by the alternative pathway. High-density lipoproteins modified with MDA were also capable of C3a generation although to a lesser degree. The presence of atheroma-associated liposomes did not result in detectable levels of complement activation markers. We conclude that MDA-modified lipoproteins may represent a possible source for complement activation within atherosclerotic lesions.
- Subjects :
- Aortic Diseases metabolism
Aortic Diseases physiopathology
Arteriosclerosis metabolism
Cholesterol isolation & purification
Cholesterol Esters isolation & purification
Complement C3a analysis
Complement C3b analysis
Complement C4 analysis
Complement Membrane Attack Complex analysis
Complement Pathway, Alternative drug effects
Humans
Lipid Peroxidation
Lipoproteins, HDL pharmacology
Liposomes chemistry
Liposomes isolation & purification
Peptide Fragments analysis
Arteriosclerosis physiopathology
Cholesterol pharmacology
Cholesterol Esters pharmacology
Complement Activation drug effects
Complement C4b
Lipoproteins, LDL pharmacology
Liposomes pharmacology
Malondialdehyde pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1015-2008
- Volume :
- 64
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pathobiology : journal of immunopathology, molecular and cellular biology
- Publication Type :
- Academic Journal
- Accession number :
- 8888272
- Full Text :
- https://doi.org/10.1159/000164012