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The effects of single and repeated phencyclidine administration on [125I] iomazenil binding in the rat brain.
- Source :
-
Neurochemistry international [Neurochem Int] 1996 Sep; Vol. 29 (3), pp. 279-87. - Publication Year :
- 1996
-
Abstract
- We measured [125I] iomazenil binding, labeling the central-type benzodiazepine receptor in 37 discrete rat brain areas following single (7.5 mg/kg, i.p.) and repeated (7.5 mg/kg/day x 14 days, i.p.) treatment with phencyclidine (PCP), a non-competitive antagonist of the N-methyl-D-aspartate(NMDA)-type glutamate receptor, using in vitro quantitative autoradiographic receptor binding assay. Both single and repeated PCP treatment produced heterogeneous changes in the rat brain in a similar manner, the magnitude of change in [125I] iomazenil binding being generally greater in the repeated treatment group than in the single treatment group. A significant increase in [125I] iomazenil binding was observed in the superficial layer (layer I-IV) of the parietal cortex in both of the PCP treatment groups and the CA1 of the hippocampus of the repeated PCP-treated group. There was a significant decrease in [125I] iomazenil binding in the piriform cortex of the repeated PCP-treated group. These results suggest that the blockade of NMDA receptor-mediated glutamatergic neurotransmission by PCP produces the compensational alterations in the central-type benzodiazepine receptor antagonist binding, and that the observed diversity may be due to dissimilar modes of organizations between glutamatergic and the GABA(gamma-aminobutyric acid)-benzodiazepine receptor complex.
- Subjects :
- Animals
Autoradiography
Brain anatomy & histology
Brain drug effects
Excitatory Amino Acid Antagonists administration & dosage
Flumazenil pharmacokinetics
Iodine Radioisotopes
Male
Phencyclidine administration & dosage
Rats
Rats, Wistar
Synaptic Transmission drug effects
Brain metabolism
Excitatory Amino Acid Antagonists pharmacology
Flumazenil analogs & derivatives
Phencyclidine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0197-0186
- Volume :
- 29
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neurochemistry international
- Publication Type :
- Academic Journal
- Accession number :
- 8885287
- Full Text :
- https://doi.org/10.1016/0197-0186(96)00006-x