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Predictors of survival in HIV-infected tuberculosis patients.
- Source :
-
AIDS (London, England) [AIDS] 1996 Mar; Vol. 10 (3), pp. 269-72. - Publication Year :
- 1996
-
Abstract
- Objective: To ascertain predictors of survival in HIV-infected tuberculosis (TB) patients.<br />Design: Retrospective cohort study.<br />Setting: New York City public hospital.<br />Patients: Fifty-four consecutive HIV-seropositive patients with newly diagnosed TB and no other AIDS-defining illnesses.<br />Main Outcome Measures: CD4+ T-lymphocyte counts, completion of anti-TB therapy, repeat hospitalizations with TB, and survival.<br />Results: Forty-five (84%) of the 54 patients died a median of 15 months after TB diagnosis (range, 1-80 months), five (9%) were alive after a median of 81 months (range, 75-84 months), and four (7%) were lost to follow-up after a median of 42 months (range, 30-66 months). In univariate analyses, disseminated TB, intrathoracic adenopathy, oral candidiasis and CD4 count depletion were each associated with decreased survival. In a multivariate analysis, CD4 count depletion was the only independent predictor of decreased survival. Repeat hospitalization with TB occurred in 10 out of 15 patients who did not complete anti-TB therapy compared with one out of 21 patients who completed anti-TB therapy (P < 0.001).<br />Conclusion: The clinical presentation of TB and CD4 count at TB diagnosis are each predictive of survival in HIV-seropositive TB patients. The CD4 count is the only independent predictor of survival.
- Subjects :
- Adult
CD4 Lymphocyte Count
Cohort Studies
Female
HIV Infections complications
HIV Infections epidemiology
Humans
Male
New York City epidemiology
Patient Compliance
Retrospective Studies
Treatment Failure
Tuberculosis complications
Tuberculosis epidemiology
HIV Infections mortality
Survival Analysis
Tuberculosis mortality
Subjects
Details
- Language :
- English
- ISSN :
- 0269-9370
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 8882666
- Full Text :
- https://doi.org/10.1097/00002030-199603000-00005