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Mortality due to ventilator-associated pneumonia or colonization with Pseudomonas or Acinetobacter species: assessment by quantitative culture of samples obtained by a protected specimen brush.
- Source :
-
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 1996 Sep; Vol. 23 (3), pp. 538-42. - Publication Year :
- 1996
-
Abstract
- Ventilator-associated pneumonia (VAP) due to multiresistant pathogens is associated with a high death rate. We analyzed the relationship between VAP due to Pseudomonas or Acinetobacter species and death by comparing the outcomes for patients colonized with these pathogens (bacterial counts of < 10(3) cfu/mL) with those for patients with pneumonia due to these pathogens (bacterial counts of > or = 10(3) cfu/mL). Samples were obtained systematically with a protected specimen brush when pneumonia was suspected. Clinical characteristics at admission to our intensive care unit and clinical features at the time of suspicion of VAP were not significantly different between colonized patients and those with VAP. Mortality rates were 29% among colonized patients and 73% among patients with VAP (P < .001). These results demonstrate a relationship between a high mortality rate and the development of pneumonia due to multiresistant, nonfermenting, gram-negative bacilli ( > or = 10(3) cfu/mL) in the lower airways of patients receiving ventilatory support.
- Subjects :
- Acinetobacter drug effects
Aged
Drug Resistance, Microbial
Female
Humans
Intensive Care Units
Male
Middle Aged
Pseudomonas drug effects
Acinetobacter pathogenicity
Pneumonia, Bacterial etiology
Pneumonia, Bacterial mortality
Pneumonia, Bacterial therapy
Pseudomonas pathogenicity
Respiration, Artificial adverse effects
Respiration, Artificial mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1058-4838
- Volume :
- 23
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Publication Type :
- Academic Journal
- Accession number :
- 8879777
- Full Text :
- https://doi.org/10.1093/clinids/23.3.538