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Solid-phase extraction and HPLC analysis of kebuzone and its metabolites in blood.
- Source :
-
Die Pharmazie [Pharmazie] 1996 Sep; Vol. 51 (9), pp. 651-3. - Publication Year :
- 1996
-
Abstract
- A HPLC method for quantification of kebuzone and its metabolites in whole blood was developed. The compounds and the internal standard were isolated from blood by solid-phase extraction on a C-18 cartridge. A blood sample was to be hemolyzed before extraction. HPLC was performed on a C-18 column with the mobile phase composed of methanol/water acidified to pH 2.7 and UV absorbance detection at 247 nm. This method has been successfully applied to a pharmacokinetic study of kebuzone and its metabolites in rabbits.
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal pharmacokinetics
Central Nervous System Depressants blood
Central Nervous System Depressants pharmacokinetics
Chromatography, High Pressure Liquid
Methaqualone blood
Methaqualone pharmacokinetics
Phenylbutazone blood
Phenylbutazone pharmacokinetics
Rabbits
Spectrophotometry, Ultraviolet
Anti-Inflammatory Agents, Non-Steroidal blood
Phenylbutazone analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0031-7144
- Volume :
- 51
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Die Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 8878255