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Sustained-release subconjunctival 5-fluorouracil.
- Source :
-
Ophthalmic surgery and lasers [Ophthalmic Surg Lasers] 1996 Sep; Vol. 27 (9), pp. 763-7. - Publication Year :
- 1996
-
Abstract
- Background and Objectives: The purpose of this research was to obtain preliminary safety and efficacy data on a novel sustained-release 5-fluorouracil (5-FU) implant in high-risk glaucoma surgical patients.<br />Patients and Methods: The implants were placed subconjunctivally in four patients undergoing high-risk trabeculectomy. The patients have been observed for approximately 2.5 years.<br />Results: In three of the four patients intraocular pressure was controlled at less than 21 mm Hg, with stabilization of the visual field. One patient had early failure. No untoward events were linked to the placement of the implant.<br />Conclusion: Sustained-release systems for subconjunctival 5-FU may be useful in filter maintenance.
- Subjects :
- Aged
Conjunctiva
Delayed-Action Preparations
Drug Implants
Female
Follow-Up Studies
Glaucoma, Open-Angle physiopathology
Glaucoma, Open-Angle surgery
Humans
Intraocular Pressure
Male
Postoperative Complications physiopathology
Trabeculectomy
Visual Acuity
Antimetabolites administration & dosage
Fluorouracil administration & dosage
Glaucoma, Open-Angle drug therapy
Postoperative Complications prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1082-3069
- Volume :
- 27
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Ophthalmic surgery and lasers
- Publication Type :
- Academic Journal
- Accession number :
- 8878194