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Effects of pentoxifylline on hemorheologic alterations induced by incremental treadmill exercise in thoroughbreds.
- Source :
-
American journal of veterinary research [Am J Vet Res] 1996 Sep; Vol. 57 (9), pp. 1364-8. - Publication Year :
- 1996
-
Abstract
- Objectives: To determine whether pentoxifylline treatment altered hematologic, rheologic, electrolyte, or blood gas test results of Thoroughbreds during submaximal treadmill exercise.<br />Animals: 5 healthy Thoroughbreds that had raced within the past year and had no history of exercise-induced pulmonary hemorrhage.<br />Procedure: Mixed venous blood samples were obtained before exercise, at treadmill speeds of 9 and 13 m/s, and 20 minutes after exercise; hematologic, rheologic, electrolyte, and blood gas test results were determined.<br />Results: Pentoxifylline treatment resulted in a 45% reduction in RBC filtration pressures for horses at rest. The improved RBC filterability persisted during treadmill exercise. Horses treated with pentoxifylline had a greater decrease in Po2 values and a lesser increase in plasma lactate concentration during treadmill exercise.<br />Conclusion: Administration of pentoxifylline improved RBC deformability of horses at rest and during treadmill exercise.<br />Clinical Relevance: Improved RBC deformability resulting from pentoxifylline treatment may reduce exercise-associated shear stress in pulmonary capillaries, thereby attenuating exercise-induced pulmonary hemorrhage.
- Subjects :
- Analysis of Variance
Animals
Blood Proteins metabolism
Blood Viscosity drug effects
Erythrocytes drug effects
Erythrocytes metabolism
Female
Lactates blood
Male
Orchiectomy
Physical Conditioning, Animal
Rheology
Electrolytes blood
Erythrocyte Deformability drug effects
Horses physiology
Oxygen blood
Pentoxifylline pharmacology
Physical Exertion
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9645
- Volume :
- 57
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- American journal of veterinary research
- Publication Type :
- Academic Journal
- Accession number :
- 8874734