Back to Search
Start Over
Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.
- Source :
-
Cell [Cell] 1996 Oct 18; Vol. 87 (2), pp. 175-85. - Publication Year :
- 1996
-
Abstract
- The guidance of developing axons in the nervous system is mediated partly by diffusible chemoattractants secreted by axonal target cells. Netrins are chemoattractants for commissural axons in the vertebrate spinal cord, but the mechanisms through which they produce their effects are unknown. We show that Deleted in Colorectal Cancer (DCC), a transmembrane protein of the immunoglobulin superfamily, is expressed on spinal commissural axons and possesses netrin-1-binding activity. Moreover, an antibody to DCC selectively blocks the netrin-1-dependent outgrowth of commissural axons in vitro. These results indicate that DCC is a receptor or a component of a receptor that mediates the effects of netrin-1 on commissural axons, and they complement genetic evidence for interactions between DCC and netrin homologs in C. elegans and Drosophila.
- Subjects :
- Amino Acid Sequence
Animals
Axons physiology
Base Sequence
Cells, Cultured
Gene Expression Regulation, Developmental
Genes, Tumor Suppressor
In Situ Hybridization
Membrane Proteins genetics
Molecular Sequence Data
Netrin-1
Protein Binding
RNA, Messenger genetics
Rats
Recombinant Proteins
Signal Transduction
Spinal Cord embryology
Spinal Cord physiology
Cell Adhesion Molecules physiology
Membrane Proteins metabolism
Nerve Growth Factors physiology
Receptors, Cell Surface genetics
Tumor Suppressor Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 0092-8674
- Volume :
- 87
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- 8861902
- Full Text :
- https://doi.org/10.1016/s0092-8674(00)81336-7