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Neurologic complications of pediatric systemic malignancies.
- Source :
-
Journal of the Formosan Medical Association = Taiwan yi zhi [J Formos Med Assoc] 1996 Mar; Vol. 95 (3), pp. 209-12. - Publication Year :
- 1996
-
Abstract
- From 1991 to 1995, we reviewed the medical records of 200 pediatric patients with systemic malignancies to study the occurrence of neurologic complications and their treatment. A total of 25 patients with neurologic complications were found. Complications included intracranial metastasis (one patient), intraspinal metastasis (one), spinal epidural compressions (three), leptomeningeal metastases (six), metabolic encephalopathy (10), opportunistic infection (one), cerebrovascular disorders (three), treatment complications (six) and paraneoplastic syndromes (two). Ten patients had seizures. One patient with acute lymphoblastic leukemia (ALL) had the unusual complication of cytomegalovirus retinitis and glaucoma. Seven patients had neurologic features at presentation. ALL was the most common malignancy (56%) and neuroblastoma (20%) was the second. Neurologic deficits are frequently seen in pediatric patients with systemic malignancies and can, in fact, be the presenting signs. Early diagnosis and treatment is important to prevent further neurologic disability.
- Subjects :
- Adolescent
Brain Diseases pathology
Central Nervous System Neoplasms pathology
Child
Child, Preschool
Female
Humans
Male
Retrospective Studies
Taiwan
Brain Diseases etiology
Central Nervous System Neoplasms secondary
Neoplasms complications
Neuroblastoma complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma complications
Subjects
Details
- Language :
- English
- ISSN :
- 0929-6646
- Volume :
- 95
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of the Formosan Medical Association = Taiwan yi zhi
- Publication Type :
- Academic Journal
- Accession number :
- 8857252