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Cloning and characterization of myr 6, an unconventional myosin of the dilute/myosin-V family.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1996 Oct 01; Vol. 93 (20), pp. 10826-31. - Publication Year :
- 1996
-
Abstract
- We have isolated cDNAs encoding a second member of the dilute (myosin-V) unconventional myosin family in vertebrates, myr 6 (myosin from rat 6). Expression of myr 6 transcripts in the brain is much more limited than is the expression of dilute, with highest levels observed in choroid plexus and components of the limbic system. We have mapped the myr 6 locus to mouse chromosome 18 using an interspecific backcross. The 3' portion of the myr 6 cDNA sequence from rat is nearly identical to that of a previously published putative glutamic acid decarboxylase from mouse [Huang, W.M., Reed-Fourquet, L., Wu, E. & Wu, J.Y. (1990) Proc. Natl. Acad. Sci. USA 87, 8491-8495].
- Subjects :
- Amino Acid Sequence
Animals
Brain metabolism
Chromosome Mapping
Cloning, Molecular
DNA, Complementary genetics
Gene Expression
Genes
Glutamate Decarboxylase genetics
Haplotypes
In Situ Hybridization
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Phylogeny
Rats
Sequence Alignment
Sequence Homology, Amino Acid
Tissue Distribution
Myosins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 93
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 8855265
- Full Text :
- https://doi.org/10.1073/pnas.93.20.10826