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Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines.

Authors :
Papanicolaou DA
Petrides JS
Tsigos C
Bina S
Kalogeras KT
Wilder R
Gold PW
Deuster PA
Chrousos GP
Source :
The American journal of physiology [Am J Physiol] 1996 Sep; Vol. 271 (3 Pt 1), pp. E601-5.
Publication Year :
1996

Abstract

In experimental animals, stress and catecholamines stimulate endogenous interleukin-6 (IL-6) secretion, whereas glucocorticoids inhibit it. To examine whether physical stress alters the secretion of IL-6 in humans, and to what extent this is correlated with catecholamines and modified by glucocorticoids, we performed high-intensity treadmill exercise test runs on 15 male volunteers, in a double-blind crossover design, after pretreatment with placebo, hydrocortisone, or dexamethasone. Plasma epinephrine and norepinephrine concentrations peaked 15 min after the start of exercise, whereas plasma IL-6 concentrations peaked twice, 15 min and 45 min after the onset of the test run. There was no difference in either the epinephrine or norepinephrine peaks among the three treatments, but the net area under the curve for IL-6 was smaller after hydrocortisone or dexamethasone than after placebo and smaller after dexamethasone than after hydrocortisone. A positive correlation was observed between peak plasma epinephrine or norepinephrine and IL-6 levels at 15 min. These findings suggest that IL-6 secretion is stimulated during exercise, possibly by catecholamines, whereas exogenous glucocorticoids attenuate this effect without affecting the catecholamine levels.

Details

Language :
English
ISSN :
0002-9513
Volume :
271
Issue :
3 Pt 1
Database :
MEDLINE
Journal :
The American journal of physiology
Publication Type :
Academic Journal
Accession number :
8843757
Full Text :
https://doi.org/10.1152/ajpendo.1996.271.3.E601