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The role of neurotransporters in excitotoxicity, neuronal cell death, and other neurodegenerative processes.
- Source :
-
Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 1996 Jul; Vol. 74 (7), pp. 365-78. - Publication Year :
- 1996
-
Abstract
- Neurotransporters are high-affinity transport proteins located in the plasma membrane of both presynaptic nerve and glial cells that mediate the removal of neurotransmitters from the synaptic cleft or represent intracellular transport systems that concentrate neurotransmitters in synaptic vesicles. They comprise three sub-groups, Na+/Cl- or Na+/K(+)-dependent cell surface transporters and H(+)-dependent transporters associated with synaptic vesicles. The new insights into neurotransporter diversity provide the means for novel approaches of studying neurotransmitter uptake processes at the molecular level, such as substrate translocation, antagonist binding, and regulation of gene expression, intracellular trafficking, and posttranslational modification. Moreover, modeling neurotransporter-related disorders and therapeutic strategies in genetically engineered animals are now feasible research strategies. Through an improved understanding of the modulation of neurotransporter function in the brain it may be possible to identify the molecular factors underlying the etiopathogenesis and pathophysiology of neurodegenerative disorders. Due to their specificity for distinct neuronal systems neurotransporters and their genes are potential targets for novel therapeutic strategies.
- Subjects :
- 1-Methyl-4-phenylpyridinium pharmacology
Base Sequence
Excitatory Amino Acids metabolism
Humans
Models, Biological
Molecular Sequence Data
N-Methyl-3,4-methylenedioxyamphetamine pharmacology
Neurotoxins pharmacology
Neurotransmitter Agents metabolism
Serotonin metabolism
Carrier Proteins metabolism
Neurons metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0946-2716
- Volume :
- 74
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of molecular medicine (Berlin, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 8841949
- Full Text :
- https://doi.org/10.1007/BF00210631