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No evidence for an inhibitory effect of beta-carotene or of canthaxanthin on the initiation of liver preneoplastic foci by diethylnitrosamine in the rat.
- Source :
-
Nutrition and cancer [Nutr Cancer] 1996; Vol. 25 (1), pp. 27-34. - Publication Year :
- 1996
-
Abstract
- To test whether beta-carotene or canthaxanthin can modulate the initiation of liver preneoplasia by diethylnitrosamine (DEN) in a sequential protocol of hepatocarcinogenesis, for three weeks male weanling rats were fed diets containing beta-carotene or canthaxanthin (300 mg/kg diet) or excess vitamin A (70,000 IU/kg diet) or were given beta-carotene by injection (9 injections at 10 mg/kg body wt ip). On Day 15, all rats were injected with 200 mg DEN/kg body wt ip; later they were submitted to 2-acetylaminofluorene treatment and to two-thirds hepatectomy, then to phenobarbital treatment, after which gamma-glutamyltranspeptidase- and placental glutathione-S-transferase-positive liver foci were histologically detected. Neither beta-carotene (fed or injected), canthaxanthin, nor an excess of dietary vitamin A had an influence on the number and size of preneoplastic liver foci, despite a significant incorporation and persistence in liver of both carotenoids, especially canthaxanthin, and of supplemental vitamin A. These results are in conflict with another report in which beta-carotene, given to rats during the initiation phase, was found to strongly inhibit DEN-induced hepatocarcinogenesis.
- Subjects :
- Animals
Canthaxanthin administration & dosage
Carcinogens
Diet
Glutathione Transferase analysis
Liver enzymology
Liver Neoplasms chemically induced
Liver Neoplasms enzymology
Male
Precancerous Conditions chemically induced
Precancerous Conditions enzymology
Rats
Rats, Wistar
beta Carotene administration & dosage
gamma-Glutamyltransferase analysis
Anticarcinogenic Agents pharmacology
Canthaxanthin pharmacology
Diethylnitrosamine
Liver Neoplasms prevention & control
Precancerous Conditions prevention & control
beta Carotene pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0163-5581
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nutrition and cancer
- Publication Type :
- Academic Journal
- Accession number :
- 8837859
- Full Text :
- https://doi.org/10.1080/01635589609514425