Back to Search
Start Over
Human immunodeficiency virus infection, the acquired immunodeficiency syndrome, and inflammatory bowel disease.
- Source :
-
Journal of clinical gastroenterology [J Clin Gastroenterol] 1996 Jul; Vol. 23 (1), pp. 24-8. - Publication Year :
- 1996
-
Abstract
- The objective of this study was to determine the effect of human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS) on inflammatory bowel disease (IBD). A retrospective survey of the medical records of St. Paul's Hospital and its AIDS-care physicians/gastroenterologists searching for patients with both HIV/AIDS and IBD was conducted. Of 1,839 hospitalized patients (4,459 hospital admissions) from 1989 to 1993, two patients with AIDS/HIV and IBD were found. The physician survey revealed four patients for a total of six patients. Four patients developed de novo IBD--two ulcerative colitis (UC), one Crohn's disease (CrD), and one indeterminate colitis (IC)--after HIV infection. Two patients had UC predating HIV seroconversion. The absolute CD4 count of patients with de novo IBD was 210-700 cells/ml at the time of IBD. The patient with IC maintained quiescent IBD from a CD4 count of 190-30 cells/ml. The other had many relapses before HIV seropositivity. With CD4 count depletion, disease activity improved. IBD medications were discontinued at a CD4 count of 130 cells/ml. Diarrhea returned at a CD4 count of 20 cells/ml; however, sigmoidoscopy was unremarkable, and mucosal biopsy revealed cryptosporidiosis without active UC. No patient had an AIDS-related illness during active IBD. Two patients followed to CD4 counts of < 30 cells/ml suffered AIDS-related infections with quiescent IBD. With a progressive decline in CD4 count, IBD disease activity may improve and remit. The CD4 count at which remission occurs may reflect severe immunodeficiency such that risk for AIDS-related infection is high. Active IBD may occur with lesser degrees of immunodeficiency.
- Subjects :
- Acquired Immunodeficiency Syndrome epidemiology
Acquired Immunodeficiency Syndrome immunology
Adult
CD4 Lymphocyte Count
Colitis, Ulcerative diagnosis
Colitis, Ulcerative epidemiology
Colon pathology
Crohn Disease diagnosis
Crohn Disease epidemiology
HIV Infections epidemiology
HIV Infections immunology
Humans
Intestinal Mucosa pathology
Male
Middle Aged
Retrospective Studies
Acquired Immunodeficiency Syndrome complications
Colitis, Ulcerative complications
Crohn Disease complications
HIV Infections complications
Subjects
Details
- Language :
- English
- ISSN :
- 0192-0790
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of clinical gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 8835895
- Full Text :
- https://doi.org/10.1097/00004836-199607000-00008