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Cleavage specificity of coxsackievirus 3C proteinase for peptide substrate.
- Source :
-
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 1996 Apr; Vol. 60 (4), pp. 705-7. - Publication Year :
- 1996
-
Abstract
- The substrate requirements of coxsackievirus 3C proteinase (3Cpro) were investigated on the C-terminal side of the scissile bond using C-terminal truncated peptides of the substrate peptide Ac-EALFQGPPV. Not only the Gln-Gly bond of Ac-EALFQG-NH2 but also the C-terminal amide group of Ac-EALFQ-NH2 was hydrolyzed by 3Cpro, suggesting that the essential residues for cleavage by coxsackievirus 3Cpro would exist within the N-terminal 5 residues.
Details
- Language :
- English
- ISSN :
- 0916-8451
- Volume :
- 60
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 8829544
- Full Text :
- https://doi.org/10.1271/bbb.60.705