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Effect of gonadotropin-releasing hormone on estrogen receptor messenger ribonucleic acid level in perifused pituitary cells.
- Source :
-
Cellular and molecular neurobiology [Cell Mol Neurobiol] 1996 Jun; Vol. 16 (3), pp. 397-402. - Publication Year :
- 1996
-
Abstract
- 1. We examined the potential effect of GnRH pulses on pituitary estrogen receptor mRNA level. 2. The treatment of perifused pituitary cell aggregates with four hourly pulses of GnRH (10nM/1 min/h) resulted in a marked increase in the steady-state level of ER mRNA (25% vs unstimulated control, n = 3). 3. No changes were observed for the LH beta mRNA. Data suggest, for the first time, that a cross-talk between the GnRH and nuclear ER may occur in the gonadotrope cells.
- Subjects :
- Animals
Cells, Cultured
Female
Luteinizing Hormone metabolism
Pituitary Gland, Anterior cytology
Pituitary Gland, Anterior metabolism
RNA, Messenger genetics
Rats
Rats, Wistar
Receptors, Estrogen biosynthesis
Gonadotropin-Releasing Hormone pharmacology
Pituitary Gland, Anterior drug effects
RNA, Messenger biosynthesis
Receptors, Estrogen genetics
Up-Regulation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0272-4340
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cellular and molecular neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 8818404
- Full Text :
- https://doi.org/10.1007/BF02088103