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Frequency and specificity of platelet-specific alloantibodies in HLA-immunized haematologic-oncologic patients.
- Source :
-
Transfusion medicine (Oxford, England) [Transfus Med] 1996 Jun; Vol. 6 (2), pp. 111-4. - Publication Year :
- 1996
-
Abstract
- The frequency and specificity of platelet-alloantibodies to human platelet antigens (HPA) -1, -3 and -5 was investigated in 59 multitransfused, HLA-immunized patients. Using the MAIPA test (monoclonal antibody specific immobilization of platelet antigens) platelet alloantibodies could be demonstrated in 10 (17%) patients. In one patient the antibody was present prior to any transfusions and probably induced by multiple previous pregnancies. This antibody was directed to HPA-5b. The remaining nine antibodies were found in patients (n = 36) with HLA-antibodies reacting with over 95% of unselected lymphocytes. In these patients the target antigens were HPA-1b in six, HPA-3a in one and both antigens in two patients. Our findings demonstrate platelet alloimmunization induced by transfusions to be restricted to patients with high HLA-immunization. 25% of these patients (9/36) show platelet-specific antibodies, primarily HPA-1b.
Details
- Language :
- English
- ISSN :
- 0958-7578
- Volume :
- 6
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Transfusion medicine (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 8809957
- Full Text :
- https://doi.org/10.1046/j.1365-3148.1996.d01-58.x