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Autoimmune myocarditis.
- Source :
-
International journal of cardiology [Int J Cardiol] 1996 May; Vol. 54 (2), pp. 171-5. - Publication Year :
- 1996
-
Abstract
- We have developed two models of myocarditis in mice. The first is produced by infection with Coxsackievirus B3; the second results from immunization with cardiac myosin. Both forms of myocarditis occur in the same genetically predisposed strains. Genetically resistant mice can be rendered susceptible to myocarditis by co-treatment with cytokines IL-1 or TNF. Moreover, the disease is inhibited by administration of an antagonist of IL-1. These models will be useful for clarifying outstanding issues related to human myocarditis or dilated cardiomyopathy.
Details
- Language :
- English
- ISSN :
- 0167-5273
- Volume :
- 54
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 8803682
- Full Text :
- https://doi.org/10.1016/0167-5273(96)02595-8