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Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development.
- Source :
-
Development (Cambridge, England) [Development] 1996 Sep; Vol. 122 (9), pp. 2719-28. - Publication Year :
- 1996
-
Abstract
- The basic helix-loop-helix proteins of the Enhancer of split complex constitute a link between activation of the transmembrane receptor Notch and the resulting effects on transcription of downstream genes. The Suppressor of Hairless protein is the intermediary between Notch activation and expression of all Enhancer of split genes even though individual genes have distinct patterns of expression in imaginal discs. A comparison between the phenotypes produced by Notch, Suppressor of Hairless and Enhancer of split mutations in the wing and thorax indicate that Suppressor of Hairless and Notch requirements are indistinguishable, but that Enhancer of split activity is only essential for a subset of developmental processes involving Notch function. Likewise, the ectopic expression of Enhancer of split proteins does not reproduce all the consequences typical of ectopic Notch activation. We suggest that the Notch pathway bifurcates after the activation of Suppressor of Hairless and that Enhancer of split activity is not required when the consequence of Notch function is the transcriptional activation of downstream genes. Transcriptional activation mediated by Suppressor of Hairless and transcriptional repression mediated by Enhancer of split could provide greater diversity in the response of individual genes to Notch activity.
- Subjects :
- Animals
Base Sequence
Basic Helix-Loop-Helix Transcription Factors
Drosophila embryology
Drosophila growth & development
Genes, Insect
Helix-Loop-Helix Motifs genetics
Molecular Sequence Data
Mutagenesis
Phenotype
RNA, Messenger genetics
RNA, Messenger metabolism
Receptors, Notch
Signal Transduction
Transcriptional Activation
Wings, Animal growth & development
DNA-Binding Proteins genetics
Drosophila genetics
Drosophila Proteins
Gene Expression Regulation, Developmental
Insect Hormones genetics
Membrane Proteins genetics
Repressor Proteins genetics
Transcription Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0950-1991
- Volume :
- 122
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Development (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 8787746
- Full Text :
- https://doi.org/10.1242/dev.122.9.2719