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Acute hemodynamic and long-term clinical effects of isradipine in patients with coronary artery disease and chronic heart failure. A double-blind, placebo-controlled study.
- Source :
-
International journal of cardiology [Int J Cardiol] 1996 Jan; Vol. 53 (1), pp. 37-43. - Publication Year :
- 1996
-
Abstract
- To assess the acute hemodynamic and long-term clinical effects of isradipine, a calcium antagonist of the dihydropyridine class, we performed a double-blind, placebo-controlled parallel study in 19 patients with coronary artery disease (CAD) and stable chronic heart failure (CHF). Their mean age was 56 +/- 5 years, and left ventricular ejection fraction (LVEF) was 0.18 +/- 0.05. Patients were treated with diuretics and digoxin only. All were clinically stable and in sinus rhythm. The acute hemodynamic study showed that (intravenous) isradipine increased cardiac index (+36%) and stroke volume index (+30%) (both P < 0.001), while systemic vascular resistance (-33%) and mean arterial pressure (-10%) decreased (both P < 0.005). Filling pressures and heart rate were not affected. Of the 19 patients, 17 completed the 12 week study; 2 patients on placebo (1 death, 1 side-effects) but no patient on isradipine (5 mg 3 times daily) dropped out. After 12 weeks, peak oxygen consumption (VO2), LVEF, echocardiographic indices, and other clinical parameters were unaffected by treatment. Repeat invasive hemodynamic measurements showed that the initial improvement by isradipine was not present anymore. In conclusion, despite a beneficial acute hemodynamic effect, isradipine has no favorable clinical influence during prolonged treatment in patients with mild to moderate CHF.
- Subjects :
- Calcium Channel Blockers pharmacology
Cardiac Output, Low physiopathology
Chronic Disease
Coronary Disease physiopathology
Double-Blind Method
Female
Hemodynamics drug effects
Humans
Isradipine pharmacology
Male
Middle Aged
Treatment Failure
Calcium Channel Blockers therapeutic use
Cardiac Output, Low drug therapy
Coronary Disease drug therapy
Isradipine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0167-5273
- Volume :
- 53
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 8776276
- Full Text :
- https://doi.org/10.1016/0167-5273(95)02506-5