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Treatment of mixed cryoglobulinemia with recombinant interferon alpha and adjuvant therapies. A prospective study on 20 patients.
- Source :
-
Annales de medecine interne [Ann Med Interne (Paris)] 1996; Vol. 147 (2), pp. 81-6. - Publication Year :
- 1996
-
Abstract
- In order to evaluate the efficacy of interferon alpha (IFNa) in mixed cryoglobulinemia (MC), a prospective multicenter clinical trial was conduced in April 1992. It consisted of treating 20 clinically symptomatic MC patients with IFNa for 26 weeks. Hepatitis C virus (HCV) infection was detected in 16 patients. A complete or partial clinical remission was obtained in 12 patients (60%). Eleven of these 12 responders (91.6%) experienced a clinical relapse less than 12 months after the end of therapy. Side effects were noted in 10 patients (50%). It was concluded that subcutaneously administered IFNa does not provide long-term remission.
- Subjects :
- Adrenal Cortex Hormones therapeutic use
Aged
Aged, 80 and over
Antiviral Agents administration & dosage
Chemotherapy, Adjuvant
Cryoglobulinemia complications
Female
Hepatitis C complications
Hepatitis C therapy
Humans
Injections, Subcutaneous
Interferon Type I administration & dosage
Male
Middle Aged
Plasma Exchange
Prospective Studies
Recombinant Proteins
Recurrence
Antiviral Agents therapeutic use
Cryoglobulinemia therapy
Interferon Type I therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0003-410X
- Volume :
- 147
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Annales de medecine interne
- Publication Type :
- Academic Journal
- Accession number :
- 8760684