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Associated daily biosynthesis of cortisol and thromboxane A2: a preliminary report.
- Source :
-
The Journal of laboratory and clinical medicine [J Lab Clin Med] 1996 Jul; Vol. 128 (1), pp. 115-21. - Publication Year :
- 1996
-
Abstract
- Cortisol is the most important hormone secreted in response to acute and chronic stress. Thromboxane A2 (TxA2) is a potent eicosanoid with vasoconstricting and proaggregatory actions. Our earlier finding of a close correlation between plasma levels of TxB2, the stable metabolite of TxA2, and cortisol in subjects with major depression but without frank hypercortisolism prompted us to investigate a possible association between TxA2 and cortisol production in nondepressed subjects. The 24-hour urinary excretion values of 2,3-dinor-TxB2 (the urinary catabolite of TxA2) and cortisol were measured by radioimmunoassay in 50 subjects divided into three groups matched for age, sex distribution, and body mass index. Group 1 consisted of 19 healthy subjects; group 2 consisted of 15 patients with type IIa hypercholesterolemia, a condition associated with a high atherothrombotic risk, but without history of atherosclerosis or evidence of this disorder documented clinically or in noninvasive diagnostic tests; and group 3 consisted of 16 patients with regional atherosclerosis (8 with cerebrovascular disease, 6 with coronary artery disease, and 2 with peripheral vascular disease). Although the three groups had similar cortisol and 2,3-dinor-TxB2 urinary values, a significant direct correlation emerged between the two catabolites in the whole study sample (r = 0.63; p < 0.0001) and the three groups (r1 = 0.62, p < 0.01; r2 = 0.78, p < 0.0001; r3 = 0.63, p < 0.01). The close association between cortisol and thromboxane A2 biosynthesis thus appears to be a general phenomenon. These findings may be important in interpreting the well-described causative link between stress and atherothrombotic cardiovascular disease.
- Subjects :
- Aged
Anxiety
Arteriosclerosis psychology
Arteriosclerosis urine
Cholesterol, HDL
Cholesterol, LDL blood
Female
Humans
Hydrocortisone urine
Hypercholesterolemia blood
Hypercholesterolemia psychology
Hypercholesterolemia urine
Male
Middle Aged
Radioimmunoassay
Reference Values
Thromboxane B2 analogs & derivatives
Thromboxane B2 urine
Triglycerides blood
Circadian Rhythm
Hydrocortisone biosynthesis
Thromboxane A2 biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2143
- Volume :
- 128
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of laboratory and clinical medicine
- Publication Type :
- Academic Journal
- Accession number :
- 8759943
- Full Text :
- https://doi.org/10.1016/s0022-2143(96)90120-1