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Interactions of N-ethylmaleimide and aluminium fluoride with GABAB receptor function in rat neocortical slices.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1995 Dec 12; Vol. 287 (2), pp. 197-200. - Publication Year :
- 1995
-
Abstract
- Interactions of N-ethylmaleimide and aluminium fluoride (AlF - 4) with GABAB receptors have been examined using spontaneously discharging rat neocortical slices. The suppression of discharges by the GABAB receptor agonist baclofen (5-10 mu M) was irreversibly prevented by N-ethylmaleimide (10-50 mu M) and its analog N-phenylmaleimide (10-50 mu M), whilst superfusion of slices with NaF (10 mM) and AlCl3 (100 mu M) to form a fluoroaluminate (AlF - 4) complex markedly potentiated the action of baclofen. The lipoxygenase inhibitors, nordihydroguaiaretic acid (10-50 mu M) and eicosatetraynoic acid (10-50 mu M) or the phospholipase A2 inhibitor bromophenacylbromide (50-100 mu M) did not affect the response to baclofen. The depressant action of baclofen is evidently mediated through G-proteins, but is not dependent on arachidonic acid metabolites.
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 287
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 8749036
- Full Text :
- https://doi.org/10.1016/0014-2999(95)00659-1