Back to Search
Start Over
Effects of noncompetitive N-methyl-D-aspartate receptor antagonists on opiate tolerance and physical dependence.
- Source :
-
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 1995 Dec; Vol. 13 (4), pp. 301-7. - Publication Year :
- 1995
-
Abstract
- Recent research has demonstrated that N-methyl-D-aspartate (NMDA) receptors, a class of excitatory amino acid receptors, may have an important role in opiate tolerance and physical dependence. Much of the evidence for this has arisen from studies that have examined the effects of NMDA receptor antagonists on these phenomena. This article summarizes research from our laboratory on the effects of NMDA receptor antagonists on opiate tolerance and dependence in rats. Noncompetitive NMDA antagonists, including MK-801, ketamine, phencyclidine, and dextrorphan have been found at low doses to inhibit the development, or acquisition, of opiate tolerance and dependence but not the expression. The results suggest that NMDA receptors have a role in the neural plasticity responsible for tolerance and dependence. Selected theoretical and therapeutic implications of these findings are discussed.
- Subjects :
- Animals
Dizocilpine Maleate pharmacology
Neuronal Plasticity drug effects
Opioid-Related Disorders physiopathology
Rats
Spinal Cord drug effects
Substance Withdrawal Syndrome physiopathology
Excitatory Amino Acid Antagonists pharmacology
Narcotics adverse effects
Opioid-Related Disorders drug therapy
Receptors, N-Methyl-D-Aspartate antagonists & inhibitors
Substance Withdrawal Syndrome drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0893-133X
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 8747754
- Full Text :
- https://doi.org/10.1016/0893-133X(95)00088-U