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Effect of pharmacotherapy on serum cholesterol levels in patients with panic disorder.
- Source :
-
Acta psychiatrica Scandinavica [Acta Psychiatr Scand] 1996 Mar; Vol. 93 (3), pp. 164-7. - Publication Year :
- 1996
-
Abstract
- It is unclear whether elevated cholesterol level is a complication of panic disorder (PD) or is associated with pharmacotherapy. We compared the total cholesterol (TC) level in 47 PD patients with that in 47 gender- and age-matched normal controls (NC), and we also examined the pre- and post-treatment TC levels. There was no sex difference in TC. Before pharmacotherapy, the mean TC level in the PD group (194.9 +/- 39.6 mg/dl) was non-significantly higher than that in the NC group (190.5 +/- 26.7 mg/dl). The mean TC level in the PD group was significantly reduced following the pharmacotherapy (post-TC: 184.7 +/- 31.0 mg/dl; t = 2.44, P < 0.02), and the subgroup treated with alprazolam (n = 26) showed markedly significant decrease of TC after the treatment (t = 2.36, P < 0.03). The TC level in the PD subgroup with agoraphobia (n = 24, 198.9 +/- 37.9 mg/dl) was slightly higher than that in the group without agoraphobia (n = 23, 190.8 +/- 41.6 mg/dl). These findings suggest that there is a relationship between cholesterol levels and treatment in PD.
- Subjects :
- Adult
Agoraphobia blood
Agoraphobia psychology
Alprazolam adverse effects
Alprazolam therapeutic use
Anti-Anxiety Agents therapeutic use
Antidepressive Agents, Tricyclic adverse effects
Antidepressive Agents, Tricyclic therapeutic use
Antipsychotic Agents therapeutic use
Female
Humans
Japan
Male
Middle Aged
Panic Disorder blood
Panic Disorder psychology
Reference Values
Treatment Outcome
Agoraphobia drug therapy
Anti-Anxiety Agents adverse effects
Antipsychotic Agents adverse effects
Cholesterol blood
Panic Disorder drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0001-690X
- Volume :
- 93
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Acta psychiatrica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 8739659
- Full Text :
- https://doi.org/10.1111/j.1600-0447.1996.tb10624.x