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An abietane diterpene and two phenolics from Salvia forskahlei.
- Source :
-
Phytochemistry [Phytochemistry] 1996 May; Vol. 42 (1), pp. 145-7. - Publication Year :
- 1996
-
Abstract
- From the roots of Salvia forskahlei a new diterpenoid, forskalinone, two new aromatic compounds, the octanol esters of cis- and trans-4-O-methyl-caffeic acid dimers, were isolated together with the known compounds stigmast-3-one, sitosterol and alpha-amyrin. The structures of the new and the known compounds were established by spectral data. The antimicrobial activity of forskalinone and the dimeric cinnamic acid esters was tested against standard bacterial strains and a yeast, namely Bacillus subtilis ATCC 6633, Staphylococcus aureus 6538P, S. epidermidis ATCC 12228, Proteus mirabilis ATCC 14153, Escherichia coli ATCC 8739, Klebsiella pneumonia ATC 4352, Pseudomonus aeruginosa ATCC 9027, Enterococcus faecalis ATCC 29212, beta-haemolytic Streptococcus and Candida albicans ATCC 10231. Forskalinone showed moderate resistance against S. epidermidis (670 micrograms ml-1) and slight activity against E. faecalis (168 micrograms ml-1). trans-4-O-Methyl-caffeic acid dimer octanol ester was inactive while the cis isomer showed a slight activity against C. albicans (156 micrograms ml-1).
- Subjects :
- Anti-Bacterial Agents
Anti-Infective Agents isolation & purification
Anti-Infective Agents pharmacology
Bacillus subtilis drug effects
Candida albicans drug effects
Diterpenes isolation & purification
Diterpenes pharmacology
Enterococcus faecalis drug effects
Escherichia coli drug effects
Klebsiella pneumoniae drug effects
Microbial Sensitivity Tests
Phenols isolation & purification
Phenols pharmacology
Plant Roots
Proteus mirabilis drug effects
Pseudomonas aeruginosa drug effects
Staphylococcus aureus drug effects
Staphylococcus epidermidis drug effects
Streptococcus agalactiae drug effects
Anti-Infective Agents chemistry
Bacteria drug effects
Diterpenes chemistry
Phenols chemistry
Plants, Medicinal
Subjects
Details
- Language :
- English
- ISSN :
- 0031-9422
- Volume :
- 42
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 8728063
- Full Text :
- https://doi.org/10.1016/0031-9422(95)00888-8