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Persistence of repetitive EEG arousals (K-alpha complexes) in RLS patients treated with L-DOPA.
- Source :
-
Sleep [Sleep] 1996 Apr; Vol. 19 (3), pp. 196-9. - Publication Year :
- 1996
-
Abstract
- Compared to normal control subjects, patients with primary restless legs syndrome (RLS) have an increased number of K-complexes, followed by bursts of electroencephalographic (EEG) alpha activity-together these are referred to as K-alpha complexes. In the present study, a large proportion of K-alpha complexes was found to be temporally associated with periodic leg movements in sleep. Because many K-alpha complexes precede the onset of movements, they cannot be considered secondary to the movements themselves. The persistence of K-alpha complexes after suppression of leg movements by means of L-DOPA further supports the hypothesis that these EEG events are a primary phenomenon. The results may have clinical implications because a large proportion of RLS patients complain of non-restorative sleep even after treatment with L-DOPA.
- Subjects :
- Adult
Antiparkinson Agents administration & dosage
Female
Humans
Levodopa administration & dosage
Male
Middle Aged
Periodicity
Sleep drug effects
Sleep Stages drug effects
Antiparkinson Agents therapeutic use
Arousal drug effects
Electroencephalography drug effects
Levodopa pharmacology
Levodopa therapeutic use
Restless Legs Syndrome drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0161-8105
- Volume :
- 19
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Sleep
- Publication Type :
- Academic Journal
- Accession number :
- 8723375
- Full Text :
- https://doi.org/10.1093/sleep/19.3.196