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Transcriptional map of the Treacher Collins candidate gene region.
- Source :
-
Genome research [Genome Res] 1996 Jan; Vol. 6 (1), pp. 26-34. - Publication Year :
- 1996
-
Abstract
- Treacher Collins syndrome (TCOF1) is a dominant disorder of craniofacial development that has been linked previosuly to a region of chromosome 5q31.3-32. Identification of recombination events in affected individuals has reduced the candidate gene region to a 0.5-Mb area between the loci RPS14 (proximal) and ANX6 [distal]. A transcriptional map of this candidate gene region, generated by analysis of exon amplification clones, has identified the genomic location of four genes, heparan sulfate-N-sulfotransferase-N-deacetylase, glutathione peroxidase, as well as two novel, previously uncharacterized genes. Each of these genes, based on their location, must be considered candidates for TCOF1 locus.
Details
- Language :
- English
- ISSN :
- 1088-9051
- Volume :
- 6
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Genome research
- Publication Type :
- Academic Journal
- Accession number :
- 8681136
- Full Text :
- https://doi.org/10.1101/gr.6.1.26