Back to Search
Start Over
Vitamin E stimulates trabecular bone formation and alters epiphyseal cartilage morphometry.
- Source :
-
Calcified tissue international [Calcif Tissue Int] 1995 Oct; Vol. 57 (4), pp. 293-300. - Publication Year :
- 1995
-
Abstract
- The effects of dietary vitamin E (VIT E) and lipids on tissue peroxidation and fatty acid composition, epiphyseal growth plate cartilage development, and trabecular bone formation were evaluated in chicks. A 2 x 2 factorial design was followed using two levels (30 and 90 IU/kg of diet) of dl-alpha-tocopheryl acetate and two different dietary lipids. The basal semipurified diet contained one of the following lipid treatments: anhydrous butter oil (40 g/kg) + soybean oil (60 g/kg), [BSO], or soybean oil (100 g/kg), [SBO]. After 14 days of feeding, the level of alpha tocopheryl in plasma was higher and thiobarbituric acid reactive substances (TBARS) were less in plasma and liver of chicks supplemented with 90 IU of VIT E compared with those given 30 IU of VIT E. Body weights and tibiotarsal bone lengths were not affected by the dietary treatments. Saturated fatty acids (14:0, 15:0, 16:0, 17:0, and 18:0) were increased in the tibiotarsal bone of chicks fed the BSO diet. In contrast, total polyunsaturated fatty acids and the ratio unsaturated fatty acids/saturated fatty acids were higher is plasma of chicks fed SBO compared with the values from chicks fed BSO. The thickness of the entire growth plate cartilage and the lower hypertrophic chondrocyte zone was significantly greater in chicks fed 90 IU/kg of VIT E. Kinetic parameters on bone histomorphometry indicated that mineral apposition rate was higher in chicks fed 90 IU of VIT E. The interaction effect between the VIT E and BSO treatments led to the highest trabecular bone formation rate among the groups. These data suggest that VIT E protects against cellular lipid peroxidation in cartilage to sustain normal bone growth and modeling.
- Subjects :
- Animals
Antioxidants administration & dosage
Bone and Bones chemistry
Bone and Bones drug effects
Chickens
Fatty Acids analysis
Fatty Acids blood
Growth Plate drug effects
Lipid Peroxidation drug effects
Lipids administration & dosage
Lipids analysis
Lipids pharmacology
Liver chemistry
Tocopherols
Vitamin E administration & dosage
Vitamin E blood
Vitamin E pharmacology
Antioxidants pharmacology
Bone Development drug effects
Calcification, Physiologic drug effects
Growth Plate growth & development
Vitamin E analogs & derivatives
alpha-Tocopherol analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0171-967X
- Volume :
- 57
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Calcified tissue international
- Publication Type :
- Academic Journal
- Accession number :
- 8673867
- Full Text :
- https://doi.org/10.1007/BF00298885