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SH2 domains: a question of independence.

Authors :
Wandless TJ
Source :
Current biology : CB [Curr Biol] 1996 Feb 01; Vol. 6 (2), pp. 125-7.
Publication Year :
1996

Abstract

The three-dimensional structures of parts of two enzymes that contain tandem Src homology 2 (SH2) domains have recently been determined. The structures suggest how the SH2 domains function in concert to regulate enzymatic activity and localization.

Subjects

Subjects :
Animals
Insulin Receptor Substrate Proteins
Intracellular Signaling Peptides and Proteins
Phosphoproteins metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatase, Non-Receptor Type 6
Protein Tyrosine Phosphatases chemistry
Protein Tyrosine Phosphatases metabolism
Protein-Tyrosine Kinases chemistry
Protein-Tyrosine Kinases metabolism
SH2 Domain-Containing Protein Tyrosine Phosphatases
ZAP-70 Protein-Tyrosine Kinase
src Homology Domains physiology

Details

Language :
English
ISSN :
0960-9822
Volume :
6
Issue :
2
Database :
MEDLINE
Journal :
Current biology : CB
Publication Type :
Academic Journal
Accession number :
8673454
Full Text :
https://doi.org/10.1016/s0960-9822(02)00440-2
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