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Role of nitric oxide in systemic hemodynamic responses to dobutamine, epinephrine, and amrinone.
- Source :
-
Journal of cardiothoracic and vascular anesthesia [J Cardiothorac Vasc Anesth] 1995 Dec; Vol. 9 (6), pp. 627-33. - Publication Year :
- 1995
-
Abstract
- Objective: This study was designed to investigate the extent to which the systemic vasodilator effects of dobutamine, epinephrine, and amrinone are modulated by the endothelium-derived relaxing factor, nitric oxide (NO).<br />Design: This was a prospective study of low and high doses of the agonists before and after inhibition of NO synthesis.<br />Setting: Experiments were performed in the basic research laboratories of the Center for Anesthesiology Research.<br />Participants: Pentobarbital-anesthetized, intact Sprague-Dawley rats were studied in seven separate groups of eight rats each.<br />Interventions: The systemic vasodilator responses to the agonists were assessed before and after the administration of the NO synthase inhibitor, NG-nitro-L-arginine methyl ester.<br />Measurements and Main Results: Decreases in systemic vascular resistance in response to dobutamine and epinephrine were not observed after inhibition of NO synthesis, whereas the decrease in systemic vascular resistance in response to amrinone was still apparent.<br />Conclusions: The results suggest that dobutamine and epinephrine produce systemic vasodilation through the release of NO, whereas amrinone produces vasodilation independent of NO release.
- Subjects :
- Animals
Arginine analogs & derivatives
Arginine pharmacology
Blood Pressure drug effects
Cardiac Output drug effects
Enzyme Inhibitors pharmacology
Heart Rate drug effects
Hemodynamics drug effects
Male
NG-Nitroarginine Methyl Ester
Nitric Oxide antagonists & inhibitors
Nitric Oxide Synthase antagonists & inhibitors
Prospective Studies
Rats
Rats, Sprague-Dawley
Stroke Volume drug effects
Vascular Resistance drug effects
Adrenergic beta-Agonists pharmacology
Dobutamine pharmacology
Epinephrine pharmacology
Nitric Oxide pharmacology
Vasodilator Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1053-0770
- Volume :
- 9
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of cardiothoracic and vascular anesthesia
- Publication Type :
- Academic Journal
- Accession number :
- 8664451
- Full Text :
- https://doi.org/10.1016/s1053-0770(05)80221-6