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[Gene transfer and radiotherapy].
[Gene transfer and radiotherapy].
- Source :
-
Bulletin du cancer [Bull Cancer] 1996 Feb; Vol. 83 (2), pp. 107-13. - Publication Year :
- 1996
-
Abstract
- Recent studies have shown that experimental tumors could be treated more efficiently with ionizing radiation if genetic material was transfered into tumor cells. Several approaches have been reported, and among them, the first one consisted of increasing the apoptotic response to radiation by modulating genes involved in the regulation of the apoptotic pathway. Indeed the modulation of p53 and bcl-2 gene expression has recently been used successfully in several experimental models to increase the apoptotic death after radiation. A second approach consisted of taking advantage of the conditional expression of some genes after exposure to ionizing radiation. Indeed, some genes exhibit a radio-inducible promoter which can be combined to a gene, able to enhance or decrease the biological effect of radiation. The irradiation of such a transgene under the control of a radio-inducible promoter can lead to a second biological effect, concomitant to the irradiation, as reported for the TNF alpha under the control of the EGR (early growth response) promoter. A third approach consisted of enhancing the effect of radiation induced tumor cell death by the expression of a suicide gene in these cells, as suggested recently for the HSV-tk (herpes virus thymidine kinase gene). These preliminary results obtained in experimental models appear to be very promising and might improve the efficacy and specificity of radiation therapy in a not too distant future.
- Subjects :
- Animals
Apoptosis genetics
Cell Death radiation effects
Gene Expression Regulation radiation effects
Genes, Tumor Suppressor radiation effects
Genetic Vectors
Humans
In Vitro Techniques
Mice
Neoplasms genetics
Neoplasms, Experimental genetics
Proto-Oncogenes radiation effects
Transcription, Genetic
Tumor Cells, Cultured
Apoptosis radiation effects
Gene Transfer Techniques
Neoplasms radiotherapy
Neoplasms, Experimental radiotherapy
Subjects
Details
- Language :
- French
- ISSN :
- 0007-4551
- Volume :
- 83
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bulletin du cancer
- Publication Type :
- Academic Journal
- Accession number :
- 8652904