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Neonatal thyroid screening of a multi-racial population.
- Source :
-
Tropical and geographical medicine [Trop Geogr Med] 1995; Vol. 47 (6), pp. 286-8. - Publication Year :
- 1995
-
Abstract
- A retrospective study on the thyroid status of 832 infants, born in Panaga Hospital in Brunei, was conducted. Despite a high degree of ethnic variability, screening for congenital hypothyroidism (CHT) included a fixed T4 and a TSH reference interval, based on a population of Malay infants. We tested their reliability for this heterologous group of infants. New T4 and TSH intervals were determined for each ethnic group and compared, revealing false positive and false negative judgements made during the period of study. Caucasian infants showed significantly higher T4 and TSH serum levels than all other ethnic groups. Regarding T4, most false positive judgements were found among the Malay infants. False negative judgements were detected among the Caucasian female infants. A new reference scheme was recommended, consisting of reference values that are applicable in neonatal thyroid screening of all infants in Panaga Hospital, regardless of their ethnic origin.
- Subjects :
- Brunei epidemiology
Female
Humans
Hypothyroidism blood
Infant, Newborn
Male
Reference Values
Reproducibility of Results
Retrospective Studies
Thyrotropin blood
Thyroxine blood
Asian People
Congenital Hypothyroidism
Cultural Diversity
Hypothyroidism ethnology
Neonatal Screening methods
White People
Subjects
Details
- Language :
- English
- ISSN :
- 0041-3232
- Volume :
- 47
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Tropical and geographical medicine
- Publication Type :
- Academic Journal
- Accession number :
- 8650741