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[Insulin producing cells as therapy in diabetes mellitus].
- Source :
-
Die Naturwissenschaften [Naturwissenschaften] 1996 Jan; Vol. 83 (1), pp. 1-5. - Publication Year :
- 1996
-
Abstract
- Even with intensive insulin therapy it is impossible to reach physiological blood glucose levels in insulin-dependent diabetes mellitus. Because of the high costs and technical problems involved in islet cell transplantation broad applicability of this therapy seems uncertain. An alternative approach is the development of molecular-engineered insulin-producing clonal cell lines. The main interest is in rodent insulinoma cell lines and neuroendocrine AtT-20ins cells. This paper reviews the current knowledge about glucose-stimulated insulin secretion and the problems that have to be solved before these cells can be used for therapy in diabetes mellitus.
- Subjects :
- Animals
Blood Glucose metabolism
Cell Line
Genetic Engineering
Glucose pharmacology
Humans
Insulin metabolism
Insulin Secretion
Rats
Rats, Nude
Recombinant Proteins biosynthesis
Transfection
Tumor Cells, Cultured
Diabetes Mellitus, Type 1 therapy
Insulin biosynthesis
Insulinoma metabolism
Neoplasm Transplantation
Pancreatic Neoplasms metabolism
Subjects
Details
- Language :
- German
- ISSN :
- 0028-1042
- Volume :
- 83
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Die Naturwissenschaften
- Publication Type :
- Academic Journal
- Accession number :
- 8637602