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Stretching of fetal membranes increases the concentration of interleukin-8 and collagenase activity.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 1996 Mar; Vol. 174 (3), pp. 843-9. - Publication Year :
- 1996
-
Abstract
- Objective: The aim of this study was to determine whether stretching of fetal membranes can increase interleukin-8 concentration and collagenase activity.<br />Study Design: Strips of whole fetal membranes, amnion, or muscles of the lower uterine segment were stretched for 2 or 4 hours. Interleukin-8 and collagenase activity were measured in homogenized control and stretched samples. Immunohistochemical staining for interleukin-8 was carried out.<br />Results: The interleukin-8 concentration increased significantly after the whole fetal membranes were stretched for 2 and 4 hours (p <0.0007 and 0.001, respectively). Also, stretching of amnion and muscles of the lower uterine segment for 2 and 4 hours increased the concentration of interleukin-8 significantly (p <0.0007 after 2 and 4 hours, respectively). Collagenase activity was significantly increased after stretching of amnion, amniochorion, and muscles of the lower uterine segment for 4 hours (p <0.0007, 0.006, and 0.0007, respectively). After stretching, samples were darkly stained for interleukin-8 compared with control nonstretched samples.<br />Conclusion: Stretching of amnion, amniochorion, and muscles of the lower uterine segment increased interleukin-8 production and collagenase activity.
Details
- Language :
- English
- ISSN :
- 0002-9378
- Volume :
- 174
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 8633654
- Full Text :
- https://doi.org/10.1016/s0002-9378(96)70311-3