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CD4 masking during human immunodeficiency virus type 1 infection, quantified on peripheral blood lymphocytes, is a potential marker of disease progression.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1996 Mar; Vol. 173 (3), pp. 565-73. - Publication Year :
- 1996
-
Abstract
- In human immunodeficiency virus type 1 (HIV-1)-infected adults, the proportion of gp120-free CD4 molecules on the surface of T lymphocytes was measured by double-epitope EIA and expressed as a CD epitope concentration ratio. In 51% of these patients (n=81), CD4 T cells showed a significant decrease (up to 100%) in the accessibility of the CD4 epitope in the D1 domain remained accessible. Of interest, a significant increase in the CD4 gp120 binding site concentration, without a change in T cell counts, was observed within 10 days after initiation of zidovudine treatment. Furthermore, CD4 masking by gp120 was associated with a poor clinical patient status. The assessment of the CD4 epitope concentration ratio is proposed as a surrogate marker of disease progression in HIV-1-infected patients.
- Subjects :
- Adult
Antiviral Agents therapeutic use
Biomarkers
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes immunology
CD4-Positive T-Lymphocytes virology
Cell Membrane immunology
Cell Membrane virology
HIV Core Protein p24 blood
HIV Envelope Protein gp120 metabolism
HIV Infections drug therapy
HIV Infections virology
Humans
T-Lymphocytes virology
Zidovudine therapeutic use
CD4 Antigens metabolism
HIV Infections immunology
HIV-1
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 173
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 8627018
- Full Text :
- https://doi.org/10.1093/infdis/173.3.565