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Poststatin, a new inhibitor of prolyl endopeptidase. IV. The chemical synthesis of poststain.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 1996 Mar; Vol. 49 (3), pp. 287-91. - Publication Year :
- 1996
-
Abstract
- Total synthesis of poststatin was achieved by both liquid phase and solid phase methods. In both methods, the (2R,3S)-3-amino-2-hydroxyvaleric acid moiety was incorporated into protected pentapeptides, and was oxidized to (S)-3-amino-2-oxovaleric acid (postine). Deprotection of the oxidized pentapeptides gave a specimen identical with natural poststatin in physico-chemical properties and prolyl endopeptidase inhibitory activity.
- Subjects :
- Amino Acid Sequence
Chemical Phenomena
Chemistry, Physical
Magnetic Resonance Spectroscopy
Methods
Molecular Sequence Data
Molecular Structure
Oligopeptides chemistry
Prolyl Oligopeptidases
Serine Proteinase Inhibitors chemistry
Spectrometry, Mass, Fast Atom Bombardment
Stereoisomerism
Oligopeptides chemical synthesis
Oligopeptides pharmacology
Serine Endopeptidases metabolism
Serine Proteinase Inhibitors chemical synthesis
Serine Proteinase Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8820
- Volume :
- 49
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 8626246
- Full Text :
- https://doi.org/10.7164/antibiotics.49.287