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Comparative studies of gamma-interferon receptor-like proteins of variola major and variola minor viruses.
- Source :
-
FEBS letters [FEBS Lett] 1996 Mar 11; Vol. 382 (1-2), pp. 79-83. - Publication Year :
- 1996
-
Abstract
- To study specific properties of the human gamma-interferon (gamma-IFN) receptor-like proteins of the highly virulent and low virulent strains of variola (smallpox) virus (VAR) recombinant plasmids determining synthesis of these proteins in E. coli cells have been constructed. The recombinant viral gamma-IFN receptor-like proteins have been found to have high interferon-neutralising activity with regard to human gamma-IFN but not murine gamma-IFN and human alpha-IFN. The variola major and variola minor proteins under study do not differ in the efficiency of human gamma-IFN antiviral activity inhibition.
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
Escherichia coli genetics
Genes, Viral genetics
Humans
Mice
Molecular Sequence Data
Receptors, Interferon chemistry
Receptors, Interferon genetics
Receptors, Interferon isolation & purification
Recombinant Fusion Proteins biosynthesis
Recombinant Fusion Proteins isolation & purification
Recombinant Fusion Proteins pharmacology
Sequence Alignment
Sequence Homology, Amino Acid
Variola virus genetics
Viral Structural Proteins genetics
Viral Structural Proteins isolation & purification
Virulence
Interferon-gamma antagonists & inhibitors
Receptors, Interferon metabolism
Variola virus pathogenicity
Viral Structural Proteins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 382
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 8612768
- Full Text :
- https://doi.org/10.1016/0014-5793(96)00069-5