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The effect of estrogen replacement therapy with or without progestogen on the fibrinolytic system and coagulation inhibitors in postmenopausal status.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 1995 Dec; Vol. 173 (6), pp. 1849-54. - Publication Year :
- 1995
-
Abstract
- Objective: The aim of this study was to analyze several fibrinolytic components and coagulation inhibitors in postmenopausal women and had to evaluate the effect of hormone replacement therapy.<br />Study Design: Several hemostatic parameters were evaluated in 75 postmenopausal women before and after 3 to 4 and 12 months of hormone therapy.<br />Results: An increase in plasma fibrinolytic activity primarily related to a significant increase in tissue-type plasminogen activator and a decrease in plasminogen activator inhibitor type 1 was observed in women receiving hormone replacement therapy. A significant decrease in protein S and lipoprotein(a) was detected under therapy. No modifications in tissue-type plasminogen activator/plasminogen activator inhibitor-1 and activated protein C/alpha 1-antitrypsin complexes, urokinase activity, plasminogen, and antithrombin III were detected.<br />Conclusions: The increase in fibrinolytic activity and the decrease in lipoprotein(a) levels observed in women receiving hormone replacement therapy could help decrease the risk of coronary disease associated with the postmenopausal state.
- Subjects :
- Administration, Cutaneous
Administration, Oral
Adult
Aged
Estradiol administration & dosage
Female
Humans
Lipoprotein(a) metabolism
Medroxyprogesterone administration & dosage
Middle Aged
Plasminogen Activator Inhibitor 1 metabolism
Progesterone Congeners administration & dosage
Protein C drug effects
Protein C metabolism
Protein S metabolism
Time Factors
Tissue Plasminogen Activator metabolism
Estradiol pharmacology
Estrogen Replacement Therapy
Fibrinolysis drug effects
Lipoprotein(a) drug effects
Medroxyprogesterone pharmacology
Postmenopause
Progesterone Congeners pharmacology
Protein S drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9378
- Volume :
- 173
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 8610774
- Full Text :
- https://doi.org/10.1016/0002-9378(95)90439-5