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Evaluation of the drug interaction between intravenous high-dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant patients.
- Source :
-
Transplantation [Transplantation] 1996 Apr 27; Vol. 61 (8), pp. 1268-72. - Publication Year :
- 1996
-
Abstract
- The purpose of this open-label, prospective study was to compare steady state concentrations and clearances of intravenously administered cyclosporine or tacrolimus with and without concomitant high-dose (400 mg/day) fluconazole in allogeneic BMT patients. Twenty-one patients were evaluable. The mean steady state cyclosporine and tacrolimus concentrations without fluconazole were 320.3 and 18.2 ng/ml and increased to 389.2 and 21.2 ng/ml, respectively, after the addition of fluconazole, corresponding to a 21% (P=0.031) and 16% (P=0.125) increase. The mean steady state clearance of cyclosporine and tacrolimus without fluconazole was 6.82 and 1.28 ml/min/kg, which decreased to 5.57 and 1.10 ml/min/kg with fluconazole, corresponding to a 21% (P=0.031) and 16% (P=0.125) decrease, respectively. The 21% difference in the cyclosporine concentration and clearance was not thought to be clinically significant. These results suggest that fluconazole's interaction with cyclosporine or tacrolimus may be a result of fluconazole's inhibition of gut metabolism, resulting in a greater extent of absorption.
- Subjects :
- Antifungal Agents pharmacokinetics
Cyclosporine pharmacokinetics
Drug Interactions
Fluconazole pharmacokinetics
Humans
Immunosuppressive Agents pharmacokinetics
Prospective Studies
Tacrolimus pharmacokinetics
Transplantation, Homologous
Antifungal Agents administration & dosage
Bone Marrow Transplantation
Cyclosporine administration & dosage
Fluconazole administration & dosage
Graft Rejection prevention & control
Immunosuppressive Agents administration & dosage
Tacrolimus administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0041-1337
- Volume :
- 61
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 8610430
- Full Text :
- https://doi.org/10.1097/00007890-199604270-00026