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The pertussis toxin liberation genes of Bordetella pertussis are transcriptionally linked to the pertussis toxin operon.
- Source :
-
Infection and immunity [Infect Immun] 1996 Apr; Vol. 64 (4), pp. 1458-60. - Publication Year :
- 1996
-
Abstract
- The DNA sequence of the pertussis toxin operon (ptx) of Bordetella pertussis predicts that transcription of the operon ends downstream from the ptxS3 gene at a possible stem-loop structure. Secretion of the assembled pertussis toxin into the culture medium required the expression of 8 genes arranged in an operon (ptl) and lying 55 bp downstream from the ptx and ptl operons are cotranscribed and coregulated by the P(TOX) promoter. Deletion of the 55-bp DNA region caused an increase in the amount of the ptl transcripts. It is likely that this DNA region is involved in regulation of the ptx-pti expression.
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 64
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 8606119
- Full Text :
- https://doi.org/10.1128/iai.64.4.1458-1460.1996