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Transient thrombotic state after abrupt discontinuation of heparin in percutaneous coronary angioplasty.
- Source :
-
American heart journal [Am Heart J] 1996 Mar; Vol. 131 (3), pp. 434-9. - Publication Year :
- 1996
-
Abstract
- Clinical and biochemical evidence of a rebound phenomenon after discontinuing thrombin inhibitors has been reported in patients with unstable angina. To investigate if a similar phenomenon occurs in patients undergoing coronary angioplasty, 14 patients were prospectively studied during and after discontinuation of heparin infusion. A transient thrombotic state identified by a significant increase in a polypeptide fragment and fibrinopeptide A was observed 3 hours after abruptly discontinuing heparin infusion. This observation may be clinically important in managing patients after coronary angioplasty.
- Subjects :
- Adult
Aged
Angina, Unstable blood
Angina, Unstable complications
Angina, Unstable drug therapy
Anticoagulants administration & dosage
Female
Heparin administration & dosage
Humans
Male
Middle Aged
Myocardial Ischemia blood
Myocardial Ischemia chemically induced
Partial Thromboplastin Time
Prospective Studies
Substance Withdrawal Syndrome
Thrombosis blood
Angioplasty, Balloon, Coronary
Anticoagulants adverse effects
Heparin adverse effects
Thrombosis chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0002-8703
- Volume :
- 131
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 8604621
- Full Text :
- https://doi.org/10.1016/s0002-8703(96)90520-7