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Clinical significance of CD45RO expression on peripheral blood mononuclear cells in HTLV-I-infected individuals.
- Source :
-
British journal of haematology [Br J Haematol] 1996 Feb; Vol. 92 (2), pp. 401-9. - Publication Year :
- 1996
-
Abstract
- The phenotype of peripheral blood mononuclear cells (PBMC) was examined in 13 healthy volunteers, 26 HTLV-I carriers, and 58 ATL patients (22 smouldering, five chronic, 24 acute, and seven lymphoma type). The percentage of CD4+, CD25+, CD28+ and CD45RO+ cells in the PBMC of the chronic and acute type patients was significantly higher than that of the volunteers, whereas the percentage of CD8+ and CD45RA+ cells in these patients was significantly low. The histogram for CD45RO fluorescence intensity (FI) revealed two patterns: pattern A consisted of CD45RO+ cells with high FI (CD45ROhigh) and intermediate FI (CD45ROint). Pattern B consisted exclusively of CD45ROhigh. Pattern A was evident in all volunteers. The percentage of subjects showing pattern B was increased in an order that reflected disease progression. In the patients with pattern A, the CD45ROint cells were CD4+ and CD8-, and the FI of CD2, CD3, and Fas within the CD45ROint cells appeared to be lower than that within the CD45ROhigh cells. The acute type patients with pattern A had a significantly longer survival curve than that of these patients with pattern B. These results suggest that the presence of CD45ROint cells may be related to protection against disease progression in HTLV-I-infected individuals.
- Subjects :
- Acute Disease
Aged
Antigens, CD metabolism
Cell Separation
Chronic Disease
Flow Cytometry
HTLV-I Infections mortality
Humans
Immunophenotyping
Leukemia, T-Cell immunology
Leukocyte Common Antigens metabolism
Middle Aged
Survival Rate
HTLV-I Infections immunology
Leukocytes, Mononuclear immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1048
- Volume :
- 92
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 8603007
- Full Text :
- https://doi.org/10.1046/j.1365-2141.1996.d01-1474.x