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Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
- Source :
-
Genes & development [Genes Dev] 1996 Feb 01; Vol. 10 (3), pp. 301-12. - Publication Year :
- 1996
-
Abstract
- The signaling protein Hedgehog (Hh) controls cell fate and polarizes tissues in both flies and vertebrates. In flies, Hh exerts its effects by opposing the function of a novel transmembrane protein, Patched, while also locally inducing patched (ptc) transcription. We have identified a mouse homolog of ptc which in many tissues is transcribed near cells making either Sonic or Indian hedgehog. In addition, ectopic Sonic hedgehog expression in the mouse central nervous system induces ptc transcription. As in flies, mouse ptc transcription appears to be indicative of hedgehog signal reception. The results support the existence of a conserved signaling pathway used for pattern formation in insects and mammals.
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
Central Nervous System embryology
DNA, Complementary genetics
Drosophila
Hedgehog Proteins
Limb Buds embryology
Mice
Mice, Mutant Strains
Molecular Sequence Data
RNA, Messenger analysis
Receptors, Cell Surface
Sequence Homology
Sequence Homology, Nucleic Acid
Drosophila Proteins
Gene Expression Regulation, Developmental
Insect Hormones genetics
Membrane Proteins genetics
Proteins genetics
Signal Transduction physiology
Trans-Activators
Subjects
Details
- Language :
- English
- ISSN :
- 0890-9369
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Genes & development
- Publication Type :
- Academic Journal
- Accession number :
- 8595881
- Full Text :
- https://doi.org/10.1101/gad.10.3.301